Even for small networks, the number of elementary flux modes may be very large. From a mathematical point of view, not all elementary flux modes are needed to describe the cone, i.e., the set of all EFMs does not form a minimal generating set, except for special cases (for example when all reactions are irreversible). ![]() The stoichiometric and thermodynamic constraints that have to hold in a metabolic network at steady-state have led to the definition of the steady-state flux cone, which comprises all possible flux distributions over the network at steady-state.Īn important concept to analyze the flux cone in a mathematically and biologically meaningful way are elementary flux modes (EFMs), which provide an inner description of the flux cone based on generating vectors. ![]() Constraint-based analysis of metabolic networks is an important area in computational biology.
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